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Monoclonal gammopathy of undetermined significance (MGUS) is a clinically asymptomatic premalignant clonal plasma cell or lymphoplasmacytic proliferative disorder. spy lyrics It is defined by the presence of a serum monoclonal protein (M protein) at a concentration 3 g/dL, a bone marrow with 10 percent monoclonal plasma cells, and absence of end-organ . gang toto